Abstract
After more than 50 years of platinum-based anticancer research only three compounds are in clinical use worldwide. The use of the well-known lead compound of this class of anticancer agents, cisplatin, is limited by its side effects and varying resistance mechanisms. Therefore, we report on platinum(ii) compounds with asparagusic acid derivatives as ligands which show interesting anticancer results on cisplatin resistant cell lines.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cisplatin / chemistry
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Cisplatin / pharmacology
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Dose-Response Relationship, Drug
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Drug Resistance, Neoplasm / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Ligands
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Molecular Structure
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry
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Organoplatinum Compounds / pharmacology*
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Structure-Activity Relationship
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Thiophenes / chemistry
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Thiophenes / pharmacology*
Substances
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Antineoplastic Agents
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Ligands
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Organoplatinum Compounds
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Thiophenes
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1,2-dithiolane-4-carboxylic acid
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Cisplatin