Emergence of Kaposi's Sarcoma Herpesvirus-Associated Complications Following Corticosteroid Use in TB-IRIS

Maura Manion; Thomas Uldrick; Mark N Polizzotto; Virginia Sheikh; Gregg Roby; Kathryn Lurain; Dorinda Metzger; JoAnn M Mican; Alice Pau; Andrea Lisco; Elizabeth Laidlaw; Dima A Hammoud; Denise Whitby; Robert Yarchoan; Irini Sereti

doi:10.1093/ofid/ofy217

Emergence of Kaposi's Sarcoma Herpesvirus-Associated Complications Following Corticosteroid Use in TB-IRIS

Open Forum Infect Dis. 2018 Oct 12;5(10):ofy217. doi: 10.1093/ofid/ofy217. eCollection 2018 Oct.

Authors

Affiliations

¹ National Institute of Allergy and Infectious Disease, National Institutes of Health (NIH), Bethesda, Maryland.
² National Cancer Institute, NIH, Bethesda, Maryland.
³ Center for Infectious Diseases Imaging, NIH, Bethesda, Maryland.
⁴ Viral Oncology Section, AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland.

Abstract

Corticosteroid use was associated with development of Kaposi's sarcoma or multicentric Castleman disease in 3 patients with mycobacterial immune reconstitution inflammatory syndrome (IRIS) treated with corticosteroids. Monitoring for development of Kaposi's sarcoma and alternative treatment may be beneficial for patients with IRIS, especially in the presence of preexisting co-infection with Kaposi's sarcoma-associated herpesvirus.

Keywords: KSHV; TB-IRIS.

Abstract

Grants and funding