DNA-Based Chemical Reaction Networks

Fan Li; Mingshu Xiao; Hao Pei

doi:10.1002/cbic.201800721

DNA-Based Chemical Reaction Networks

Chembiochem. 2019 May 2;20(9):1105-1114. doi: 10.1002/cbic.201800721. Epub 2019 Mar 12.

Authors

Fan Li^{1

2}, Mingshu Xiao¹, Hao Pei¹

Affiliations

¹ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, 200241, Shanghai, P.R. China.
² Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Nanhai Avenue 3688, 518060, Shenzhen, Guangzhou, P.R. China.

PMID: 30575247
DOI: 10.1002/cbic.201800721

Abstract

Motivated by complex molecular networks of biological organisms, which enable control of the temporal and spatial concentrations of molecules, the bottom-up development of artificial chemical reaction networks has received renewed interest from biochemists. Based on hybridization and strand-displacement reactions, DNA-based chemical reaction networks (D-CRNs) provide a promising method to describe and analyze (bio)chemical systems, depending on their high programmability and directionality. Herein, progress in the development of D-CRNs is discussed, and an overview of significant biochemistry applications based on D-CRNs reported in recent decades is provided. Furthermore, opportunities and future directions for research into D-CRNs in biochemistry are also discussed.

Keywords: DNA; DNA recognition; biotechnology; chemical reaction networks; strand-displacement reactions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chemistry Techniques, Synthetic / methods
Computers, Molecular
DNA / chemistry*
DNA / genetics
Nanotechnology / methods
Nucleic Acid Hybridization
Theranostic Nanomedicine / methods

Substances

DNA