STAT1 gain-of-function compromises skin host defense in the context of IFN-γ signaling

J Allergy Clin Immunol. 2019 Apr;143(4):1626-1629.e5. doi: 10.1016/j.jaci.2018.11.033. Epub 2018 Dec 18.

Affiliations

¹ Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.
² Department of Internal Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, The Netherlands.
³ Department of Internal Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, The Netherlands. Electronic address: [email protected].

PMID: 30576757
DOI: 10.1016/j.jaci.2018.11.033

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Candidiasis, Chronic Mucocutaneous / genetics
Candidiasis, Chronic Mucocutaneous / immunology*
Candidiasis, Chronic Mucocutaneous / metabolism
Cells, Cultured
Cornified Envelope Proline-Rich Proteins / metabolism
Gain of Function Mutation
Humans
Interferon-gamma / immunology*
Keratinocytes / metabolism*
Keratinocytes / pathology*
STAT1 Transcription Factor / genetics*
Signal Transduction / immunology
Skin / immunology

Substances

Cornified Envelope Proline-Rich Proteins
STAT1 Transcription Factor
STAT1 protein, human
Interferon-gamma

Supplementary concepts

Candidiasis familial chronic mucocutaneous, autosomal recessive