Potential role of orbitofrontal surface morphology on social and cognitive functions in high-risk subjects for psychosis and schizophrenia patients

Psychiatry Res Neuroimaging. 2019 Jan 30:283:92-95. doi: 10.1016/j.pscychresns.2018.12.002. Epub 2018 Dec 5.

Abstract

This MRI study examined the surface morphology of the orbitofrontal cortex (OFC) and its relation to social and cognitive functions in 38 individuals with at-risk mental state (ARMS) and 63 schizophrenia patients in comparison with 61 healthy controls. The ARMS and schizophrenia groups had increased right OFC Type III expression and fewer orbital sulci, which were partly associated with social and cognitive impairments. OFC underdevelopment may underlie vulnerability to psychosis, as well as the core clinical features of the illness.

Keywords: Cognition; Orbitofrontal cortex; Social function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cognition / physiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Prefrontal Cortex / diagnostic imaging*
  • Prospective Studies
  • Psychotic Disorders / diagnostic imaging*
  • Psychotic Disorders / psychology
  • Risk Factors
  • Schizophrenia / diagnostic imaging*
  • Schizophrenic Psychology
  • Social Behavior*
  • Young Adult