A 10-Month-Old Infant Presenting With Signs of Precocious Puberty Secondary to a Sclerosing Stromal Tumor of the Ovary in the Absence of Hormonal Elevation

Pediatr Dev Pathol. 2019 Jul-Aug;22(4):375-379. doi: 10.1177/1093526618819605. Epub 2018 Dec 21.

Abstract

Precocious puberty in an infant is an alarming and infrequent finding, making the differential diagnosis difficult for practitioners. Precocious puberty secondary to a sclerosing stromal tumor (SST) of the ovary is rare. We present a case of a child that began precocious puberty at 3 months of age including development of breast buds, pubic hair, growth spurt, and menarche 5 days prior to presenting to pediatric endocrinology at 10 months. She underwent right salpingo-oophorectomy which demonstrated a soft tissue mass occupying almost the entire ovary with a tan-pink fleshy cut surface. Histological examination confirmed a variant of SST. This case represents an extremely young onset of precocious puberty secondary to a variant of SST without hormonal elevation.

Keywords: breast bud development; menarche; ovarian tumor; precocious puberty; sclerosing stromal tumor; thelarche.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Immunohistochemistry
  • Infant
  • Ovarian Neoplasms / diagnostic imaging*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Ovary / diagnostic imaging
  • Ovary / pathology
  • Puberty, Precocious / diagnostic imaging*
  • Puberty, Precocious / pathology
  • Puberty, Precocious / surgery
  • Tomography, X-Ray Computed
  • Treatment Outcome