Successful lung transplantation for chronic Mycobacterium abscessus infection in advanced cystic fibrosis, a case series

Transpl Infect Dis. 2019 Apr;21(2):e13046. doi: 10.1111/tid.13046. Epub 2019 Jan 13.

Abstract

Pulmonary Mycobacterium abscessus infection in cystic fibrosis (CF) patients is difficult to treat and considered a contra-indication for lung transplantation in most centers. We present four CF patients with chronic pulmonary M abscessus infection, in whom lung transplantation was performed. Through intensive treatment before transplantation, we achieved control of the infection in all but one patient. After a mean of 16 months of follow up, 3 patients are doing well, without evidence of local or disseminated recurrence. One patient died early post-transplant due to an unrelated cause. These findings support the possibility of lung transplantation with favorable outcome in CF patients with M abscessus infection.

Keywords: Mycobacterium abscessus; cystic fibrosis; lung transplantation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Chronic Disease
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / microbiology*
  • Cystic Fibrosis / surgery
  • Female
  • Humans
  • Lung / microbiology*
  • Lung Transplantation*
  • Male
  • Mycobacterium Infections, Nontuberculous / drug therapy*
  • Nontuberculous Mycobacteria / drug effects
  • Young Adult

Substances

  • Anti-Bacterial Agents