Possible involvement of protease inhibitor ras proteins in malignant transformation

Biol Chem Hoppe Seyler. 1988 May:369 Suppl:239-41.

Abstract

Based on our recent finding that human c-Ha-ras gene products (p21s) inhibit the activities of thiol proteinases, a possible new model for malignant transformation is proposed. The model involves a new concept that p21s can cause effects on the protein kinase activities of growth factor receptors by affecting down regulation of the receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cathepsin L
  • Cathepsins / antagonists & inhibitors
  • Cell Transformation, Neoplastic*
  • Cysteine Endopeptidases
  • Endopeptidases*
  • Humans
  • Models, Biological
  • Protease Inhibitors / pharmacology*
  • Protein Kinases / metabolism
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins p21(ras)
  • Staphylococcal Protein A / metabolism

Substances

  • Protease Inhibitors
  • Proto-Oncogene Proteins
  • Staphylococcal Protein A
  • Protein Kinases
  • Cathepsins
  • Endopeptidases
  • Cysteine Endopeptidases
  • CTSL protein, human
  • Cathepsin L
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)