First case of acute respiratory distress syndrome and alimentary tract hemorrhage following mass ingestion of methylisothiazolinone

Drug Chem Toxicol. 2019 May;42(3):317-320. doi: 10.1080/01480545.2018.1515217. Epub 2019 Jan 4.

Abstract

The frequency of methylisothiazolinone (MIT)-related health concerns regarding allergic contact dermatitis with a spongiotic reaction pattern and restrictive lung function indicating peripheral airway dysfunction caused by the use of humidifier disinfectant is increasingly rising. There is a limited number of evidences supporting the environmentally acute and mass exposure to MIT resulting in acute respiratory distress syndrome (ARDS). Here, we report the first case of ARDS and alimentary tract hemorrhage following mass ingestion of methylisothiazolinone.

Keywords: Methylisothiazolinone (MIT); acute respiratory distress syndrome (ARDS); alimentary tract hemorrhage.

Publication types

  • Case Reports

MeSH terms

  • Accidents
  • Adult
  • Anti-Infective Agents / poisoning*
  • Gastrointestinal Hemorrhage / chemically induced*
  • Gastrointestinal Hemorrhage / complications
  • Gastrointestinal Hemorrhage / diagnosis
  • Gastrointestinal Hemorrhage / therapy
  • Humans
  • Male
  • Respiratory Distress Syndrome / chemically induced*
  • Respiratory Distress Syndrome / complications
  • Respiratory Distress Syndrome / diagnosis
  • Respiratory Distress Syndrome / therapy
  • Thiazoles / poisoning*
  • Treatment Outcome

Substances

  • Anti-Infective Agents
  • Thiazoles
  • 2-methyl-4-isothiazolin-3-one