Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner

Thromb Haemost. 2019 Feb;119(2):348-351. doi: 10.1055/s-0038-1676769. Epub 2019 Jan 4.

Authors

Raquel Guillamat Prats¹, Martina Rami¹, Larisa Ring¹, Petteri Rinne^{1

2}, Estelle Lauer³, Sebastien Lenglet³, Aurelien Thomas^{3

4}, Sabrina Pagano⁵, Nicolas Vuilleumier⁵, Benjamin F Cravatt⁶, Christian Weber^{1

7

8}, Alexander Faussner¹, Sabine Steffens^{1

7}

Affiliations

¹ Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians University (LMU) of Munich, Munich, Germany.
² Institute of Biomedicine, University of Turku, Turku, Finland.
³ Unit of Toxicology, CURML, Lausanne University Hospital, Geneva University Hospitals, Geneva, Switzerland.
⁴ Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
⁵ Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland.
⁶ Department of Chemical Physiology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States.
⁷ German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
⁸ Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

PMID: 30609444
DOI: 10.1055/s-0038-1676769

No abstract available

Georg Thieme Verlag KG Stuttgart · New York.

MeSH terms

Animals
Aorta / metabolism
Atherosclerosis / blood*
Crosses, Genetic
Diglycerides / metabolism
Endocannabinoids / metabolism
Female
Immunoglobulin M / blood*
Mice
Mice, Knockout, ApoE
Monoacylglycerol Lipases / blood*
Monoacylglycerol Lipases / deficiency*
Phenotype
Plaque, Atherosclerotic / genetics
Plasma / immunology
Receptor, Cannabinoid, CB2 / blood*
Signal Transduction

Substances

Diglycerides
Endocannabinoids
Immunoglobulin M
Receptor, Cannabinoid, CB2
Monoacylglycerol Lipases