FoxP3+ CXCR5+ CD4+ T cell frequencies are increased in peripheral blood of patients with primary Sjögren's syndrome

M Ivanchenko; L A Aqrawi; A Björk; M Wahren-Herlenius; K Chemin

doi:10.1111/cei.13244

FoxP3⁺ CXCR5⁺ CD4⁺ T cell frequencies are increased in peripheral blood of patients with primary Sjögren's syndrome

Clin Exp Immunol. 2019 Mar;195(3):305-309. doi: 10.1111/cei.13244. Epub 2019 Jan 10.

Authors

M Ivanchenko¹, L A Aqrawi², A Björk¹, M Wahren-Herlenius¹, K Chemin¹

Affiliations

¹ Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
² Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway.

Abstract

We recently explored the expression of CXCR5 on T and B cells from peripheral blood of patients with primary Sjögren's syndrome (SS). Here we investigated the frequency of CD25⁺ FoxP3⁺ CD4⁺ regulatory T cells (T_regs ) among CXCR5⁺ CD4⁺ follicular cells in the same cohort of patients. We confirm that the frequency of T_regs among follicular T cells is increased in SS patients and also provide novel data showing an increased frequency of PD-1 expressing cells among CXCR5⁺ FoxP3⁺ CD4⁺ T cells.

Publication types

Letter
Comment

MeSH terms

Forkhead Transcription Factors
Genotype
Humans
Receptors, CXCR5
Salivary Glands
Sjogren's Syndrome*
T-Lymphocytes, Regulatory

Substances

CXCR5 protein, human
FOXP3 protein, human
Forkhead Transcription Factors
Receptors, CXCR5