Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data

Gastroenterology. 2019 Apr;156(5):1345-1353.e4. doi: 10.1053/j.gastro.2019.01.002. Epub 2019 Jan 10.

Abstract

Background & aims: Inflammatory bowel diseases (IBDs) exist worldwide, with high prevalence in North America. IBD is complex and costly, and its increasing prevalence places a greater stress on health care systems. We aimed to determine the past current, and future prevalences of IBD in Canada.

Methods: We performed a retrospective cohort study using population-based health administrative data from Alberta (2002-2015), British Columbia (1997-2014), Manitoba (1990-2013), Nova Scotia (1996-2009), Ontario (1999-2014), Quebec (2001-2008), and Saskatchewan (1998-2016). Autoregressive integrated moving average regression was applied, and prevalence, with 95% prediction intervals (PIs), was forecasted to 2030. Average annual percentage change, with 95% confidence intervals, was assessed with log binomial regression.

Results: In 2018, the prevalence of IBD in Canada was estimated at 725 per 100,000 (95% PI 716-735) and annual average percent change was estimated at 2.86% (95% confidence interval 2.80%-2.92%). The prevalence in 2030 was forecasted to be 981 per 100,000 (95% PI 963-999): 159 per 100,000 (95% PI 133-185) in children, 1118 per 100,000 (95% PI 1069-1168) in adults, and 1370 per 100,000 (95% PI 1312-1429) in the elderly. In 2018, 267,983 Canadians (95% PI 264,579-271,387) were estimated to be living with IBD, which was forecasted to increase to 402,853 (95% PI 395,466-410,240) by 2030.

Conclusion: Forecasting prevalence will allow health policy makers to develop policy that is necessary to address the challenges faced by health systems in providing high-quality and cost-effective care.

Keywords: Crohn Disease; Epidemiology; Forecast Modeling; Ulcerative Colitis.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administrative Claims, Healthcare
  • Adolescent
  • Adult
  • Age Distribution
  • Canada / epidemiology
  • Child
  • Child, Preschool
  • Databases, Factual
  • Female
  • Forecasting
  • History, 21st Century
  • Humans
  • Infant
  • Infant, Newborn
  • Inflammatory Bowel Diseases / diagnosis
  • Inflammatory Bowel Diseases / epidemiology*
  • Inflammatory Bowel Diseases / history
  • Male
  • Middle Aged
  • Models, Statistical*
  • Prevalence
  • Retrospective Studies
  • Sex Distribution
  • Time Factors
  • Young Adult