We present a case of paraneoplastic systemic sclerosis (SSc) and myositis associated to a multiple myeloma (MM) in a 52-year-old Caucasian man. After MM treatment, skin and muscle changes improved, with no further relapses. Although rare, "scleroderma-like" or myositis lesions may be associated with MM. However, to the best of our knowledge, this is the first case reporting these two clinical conditions simultaneously associated with MM.