Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Mei-Chuan Chen; Guei-Jane Wang; Yueh-Hsiung Kuo; Yin-Ru Chiang; Ting-Yu Cho; Yu-Ming Ju; Tzong-Huei Lee

doi:10.1016/j.jfda.2018.05.007

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

J Food Drug Anal. 2019 Jan;27(1):111-117. doi: 10.1016/j.jfda.2018.05.007. Epub 2018 Jun 18.

Authors

Mei-Chuan Chen^{1

2}, Guei-Jane Wang^{3

4

5}, Yueh-Hsiung Kuo^{6

7}, Yin-Ru Chiang⁸, Ting-Yu Cho¹, Yu-Ming Ju⁹, Tzong-Huei Lee¹⁰

Affiliations

¹ Graduate Institute of Pharmacognosy, Taipei, Taiwan.
² The Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, Taipei Medical University, Taipei, Taiwan.
³ School of Medicine, Graduate Institute of Clinical Medical Science and Biomedical Sciences, China Medical University, Taichung, Taiwan.
⁴ Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
⁵ Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
⁶ Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
⁷ Department of Biotechnology, Asia University, Taichung, Taiwan.
⁸ Biodiversity Research Center, Academia Sinica, Taipei, Taiwan.
⁹ Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan.
¹⁰ Institute of Fisheries Science, National Taiwan University, Taipei, Taiwan.

Abstract

Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with E_max values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.

Keywords: Anti-inflammation; Fimbriether; Isoprenyl phenolic ether; Nitric oxide inhibition; Xylaria fimbriata.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aorta, Thoracic / drug effects
Aorta, Thoracic / physiology
Ethers / isolation & purification
Ethers / pharmacology*
Isoptera / microbiology*
Macrophages / drug effects
Macrophages / metabolism
Mice
Mice, Inbred C57BL
Nitric Oxide / metabolism
Phenols / isolation & purification
Phenols / pharmacology*
RAW 264.7 Cells
Vasoconstrictor Agents / isolation & purification
Vasoconstrictor Agents / pharmacology
Xylariales / chemistry*
Xylariales / isolation & purification

Substances

Ethers
Phenols
Vasoconstrictor Agents
Nitric Oxide

Grants and funding

This work was supported by grant-in-aid from the Taiwan Ministry of Science and Technology (MOST104-2320-B-002-007-MY3) for THLee, the China Medical University Hospital Foundation (DMR-105-091) for GJWang, the China Medical University under the Aim for Top University of the Ministry of Education, Taiwan (CHM106-5-2), and Taiwan Ministry of Health and Welfare Clinical Trial Center, Taiwan (MOHW 106- TDU-B-212-113004) for YHKuo.