Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion

Shijie Song; Xiaoyung Kong; Juan Sanchez-Ramos

doi:10.1007/978-1-4939-9007-8_18

Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion

Methods Mol Biol. 2019:1919:227-235. doi: 10.1007/978-1-4939-9007-8_18.

Authors

Shijie Song^{1

2}, Xiaoyung Kong^{3

4

5}, Juan Sanchez-Ramos^{6

7}

Affiliations

¹ Department of Neurology and Neurosurgery, University of South Florida, Tampa, FL, USA. [email protected].
² Department of Neurology, James A. Haley VAH Research Service, University of South Florida, Tampa, FL, USA. [email protected].
³ Department of Neurology and Neurosurgery, University of South Florida, Tampa, FL, USA.
⁴ College of Medicine Neurology, University of South Florida, Tampa, FL, USA.
⁵ College of Medicine Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, USA.
⁶ Department of Neurology and Neurosurgery, University of South Florida, Tampa, FL, USA. [email protected].
⁷ Department of Neurology, James A. Haley VAH Research Service, University of South Florida, Tampa, FL, USA. [email protected].

PMID: 30656634
DOI: 10.1007/978-1-4939-9007-8_18

Abstract

Brief stereotaxic insertion and removal of a microneedle into the hippocampus of mice result in stimulation of hippocampal neurogenesis. This approach has been previously applied to a mouse model of Alzheimer's disease (Song et al., Cell Transplant 25:1853-1861, 2016). Further studies of fundamental cellular mechanisms of the brain's response to micro-injury will be useful for investigation of potential neuroprotective and deleterious effects of targeted microlesions and deep brain stimulation in neurodegenerative diseases.

Keywords: Astrocytosis; Brain repair; Cytokines; Focal brain injury; Microgliosis; Neurogenesis.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Acupuncture*
Animals
Biomarkers
Fluorescent Antibody Technique
Hippocampus / metabolism*
Immunohistochemistry
Mice
Neurogenesis*
Physical Stimulation*

Substances

Biomarkers

Grants and funding

I01 BX004037/BX/BLRD VA/United States