Randomized controlled trial evaluating the antimicrobial efficacy of chlorhexidine gluconate and para-chloro-meta-xylenol handwash formulations in real-world doses

Am J Infect Control. 2019 Jun;47(6):726-728. doi: 10.1016/j.ajic.2018.10.027. Epub 2019 Jan 18.

Abstract

Chlorhexidine gluconate-based soaps have become the gold standard for handwashing in critical care settings and para-chloro-meta-xylenol is an effective alternative antibacterial active ingredient. This study benchmarked 2 novel foaming handwashes, compared to a bland soap for antimicrobial effectiveness using the health care personnel handwash method at realistic soap doses (0.9 mL and 2.0 mL). To our knowledge, this is the first published efficacy study on realistic soap doses. Both soaps met Food and Drug Administration success criteria.

Keywords: Antibacterial; Foaming handwashes; Hand hygiene; Health care personnel; Soap.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Infective Agents, Local / administration & dosage*
  • Chlorhexidine / administration & dosage
  • Chlorhexidine / analogs & derivatives*
  • Female
  • Hand Disinfection / methods*
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome
  • Xylenes / administration & dosage*
  • Young Adult

Substances

  • Anti-Infective Agents, Local
  • Xylenes
  • chloroxylenol
  • chlorhexidine gluconate
  • Chlorhexidine