Distribution of Clinical NDM-1-Producing Gram-Negative Bacteria in Brazil

Microb Drug Resist. 2019 Apr;25(3):394-399. doi: 10.1089/mdr.2018.0240. Epub 2019 Jan 24.

Abstract

New Delhi metallo-β-lactamase (NDM)-producing bacteria have been identified at a worrying rate in Brazil since 2013. Owing to the need to understand the extent of their spread, this study reports the dissemination of blaNDM in different species of Gram-negative bacilli in different regions and states of Brazil. A total of 81 isolates from nine states were studied, including 11 species. All isolates carried blaNDM-1 variant and were considered multidrug resistant. Colistin and amikacin were the agents with higher activity compared with the other drugs tested. The findings indicate that the NDM-1 enzyme is already widespread in the country.

Keywords: Gram-negative bacilli; New Delhi metallo-β-lactamase; dissemination.

MeSH terms

  • Amikacin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Brazil / epidemiology
  • Colistin / therapeutic use
  • Drug Resistance, Multiple, Bacterial / genetics
  • Gram-Negative Bacteria / genetics*
  • Gram-Negative Bacteria / isolation & purification*
  • Gram-Negative Bacterial Infections / drug therapy
  • Gram-Negative Bacterial Infections / epidemiology*
  • Gram-Negative Bacterial Infections / microbiology
  • Humans
  • Microbial Sensitivity Tests / methods
  • Tertiary Care Centers
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Amikacin
  • beta-Lactamases
  • beta-lactamase NDM-1
  • Colistin