[The development of diagnostic of acute endometritis on the basis of modeling and cluster analysis of parameters of local immunity]

Klin Lab Diagn. 2018;63(4):239-242. doi: 10.18821/0869-2084-2018-63-4-239-242.
[Article in Russian]

Abstract

The acute endometritis provoking expressed disorders of local immunity is considered as one of the prevalent complications of postnatal period and abortions. The purpose of study is to develop diagnostic of acute endometritis on the basis of applied correlation modeling and cluster analysis techniques diagnostically priority-driven immunological indices of vaginal cervical mucus. The sample included main group (154 patients with acute endometritis) and control group (103 patients with uncomplicated post-natal period). Both groups were subjected to enzyme-linked immunosorbent assay to analyze content of immunoglobulins, components of complement and lysozyme in vaginal cervical mucus. The sampling of diagnostically significant indices was implemented using correlation and cluster analysis techniques. It is established that chief diagnostic indices of local immunity in case of acute endometritis are IG M, sIg A, С4 components of complement and lysozyme. The established diagnostically significant parameters of local immunity provide development of detection of acute endometritis according less number of indices.

Keywords: acute endometritis; cluster analysis; correlation analysis; enzyme-linked immunosorbent assay; local immunity.

MeSH terms

  • Complement System Proteins / analysis
  • Endometritis / diagnosis*
  • Endometritis / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunity
  • Immunoglobulins / analysis
  • Mucus / chemistry*
  • Muramidase / analysis
  • Pregnancy
  • Vagina / chemistry*

Substances

  • Immunoglobulins
  • Complement System Proteins
  • Muramidase