Romidepsin enhances the efficacy of cytarabine in vivo, revealing histone deacetylase inhibition as a promising therapeutic strategy for KMT2A-rearranged infant acute lymphoblastic leukemia

Haematologica. 2019 Jul;104(7):e300-e303. doi: 10.3324/haematol.2018.192906. Epub 2019 Jan 24.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology*
  • Apoptosis
  • Cell Proliferation
  • Cytarabine / administration & dosage
  • Depsipeptides / administration & dosage
  • Drug Synergism*
  • Female
  • Gene Rearrangement*
  • Histone Deacetylase Inhibitors / pharmacology
  • Histone Deacetylases / chemistry*
  • Histone-Lysine N-Methyltransferase / genetics*
  • Humans
  • Infant
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Substances

  • Depsipeptides
  • Histone Deacetylase Inhibitors
  • KMT2A protein, human
  • Cytarabine
  • Myeloid-Lymphoid Leukemia Protein
  • romidepsin
  • Histone-Lysine N-Methyltransferase
  • Histone Deacetylases