Using flowable gelatin in anterior cervical spine surgery in real-world practice: a retrospective cohort study

J Comp Eff Res. 2019 Apr;8(5):317-326. doi: 10.2217/cer-2018-0121. Epub 2019 Jan 25.

Abstract

Aim: To assess the clinical and economic impact of flowable gelatin hemostatic matrix (FGHM) in anterior cervical spine surgery (ACSS).

Patients & methods: A total of 451 patients with performed ACSS were included to compare FGHM with conventional hemostatic methods for clinical and cost outcomes using propensity score matching method.

Results: The comparisons of the matched 125 pairs observed that FGHM was associated with significantly lower blood transfusion volume (11.2 vs 36.3 ml; p = 0.039), shorter postsurgery hospital stay length (3.7 vs 4.7 days; p = 0.002), shorter operation time (103.5 vs 117.7 min; p = 0.004), lower drainage placement rate (51.2 vs 89.6%; p < 0.001) and also lower total hospital costs (median ¥64,717 vs ¥65,064; p = 0.035).

Conclusion: Use of FGHM in ACSS improved perioperative outcomes without increasing hospital costs.

Keywords: anterior cervical spine surgery; flowable gelatin hemostatic matrix; hemostasis; hospital costs; propensity scored matching.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Transfusion / statistics & numerical data
  • Cervical Vertebrae / surgery*
  • Diskectomy / methods*
  • Female
  • Gelatin / economics
  • Gelatin / therapeutic use*
  • Hemostatics / therapeutic use*
  • Hospital Costs
  • Humans
  • Length of Stay / statistics & numerical data
  • Male
  • Middle Aged
  • Models, Economic
  • Operative Time
  • Propensity Score
  • Retrospective Studies
  • Spinal Fusion / methods*

Substances

  • Hemostatics
  • Gelatin