Comparison of the screening ability between the 32-item Hypomania Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ) for bipolar disorder: A meta-analysis and systematic review

Yuan-Yuan Wang; Dan-Dan Xu; Rui Liu; Yuan Yang; Sandeep Grover; Gabor S Ungvari; Brian J Hall; Gang Wang; Yu-Tao Xiang

doi:10.1016/j.psychres.2019.01.061

Comparison of the screening ability between the 32-item Hypomania Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ) for bipolar disorder: A meta-analysis and systematic review

Psychiatry Res. 2019 Mar:273:461-466. doi: 10.1016/j.psychres.2019.01.061. Epub 2019 Jan 18.

Authors

Yuan-Yuan Wang¹, Dan-Dan Xu², Rui Liu³, Yuan Yang⁴, Sandeep Grover⁵, Gabor S Ungvari⁶, Brian J Hall⁷, Gang Wang⁸, Yu-Tao Xiang⁹

Affiliations

¹ Faculty of Health and Life Sciences, De Montfort University, Leicester, United Kingdom; Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China.
² Faculty of science, Harbin University, Heilongjiang province, China.
³ The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, School of Mental Health, Beijing, China.
⁴ Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China; Department of Psychiatry and Psychology, Southern Medical University Nanfang Hospital, Guangdong, China.
⁵ Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
⁶ University of Notre Dame Australia, Fremantle, Australia; Division of Psychiatry, School of Medicine, University of Western Australia, Perth, Australia.
⁷ Global and Community Mental Health Research Group, Department of Psychology, University of Macau, Macao SAR, China; Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
⁸ The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, School of Mental Health, Beijing, China. Electronic address: [email protected].
⁹ Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China. Electronic address: [email protected].

PMID: 30684793
DOI: 10.1016/j.psychres.2019.01.061

Abstract

The frequent misdiagnosis of bipolar disorder (BD) is associated with detrimental consequences and inappropriate treatments. The 32-item Hypomania Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ) are widely used self-report screening instruments for BD. This is a systematic review and meta-analysis to compare the psychometric properties of the HCL-32 and the MDQ based on the same patient samples. Two reviewers systematically and independently searched PubMed, PsycINFO, EMBASE, Web of Science, and Cochrane Library databases. Studies using the HCL-32 and MDQ concurrently and reporting their psychometric properties were included. Eleven studies that met the entry criteria were included in the systematic review, and 9 studies with relevant data were included in the meta-analysis. Using study-defined cutoffs, summary sensitivities were 82% (95% CI: 72%-89%) and 80% (95% CI: 71%-86%), while specificities were 57% (95% CI: 48%-66%) and 70% (95% CI: 59%-71%) for the HCL-32 and the MDQ respectively. Both the HCL-32 and the MDQ have acceptable psychometric properties to identify BD and appear to be useful screening tools for BD.

Keywords: Bipolar disorder; CRD42018109267; HCL-32; MDQ; Meta-analysis; Screening.

Publication types

Comparative Study
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Adult
Bipolar Disorder / diagnosis*
Checklist / statistics & numerical data*
Diagnostic Errors
Female
Humans
Male
Mass Screening / methods
Mass Screening / statistics & numerical data*
Psychometrics / methods
Psychometrics / statistics & numerical data*
Reproducibility of Results
Sensitivity and Specificity
Surveys and Questionnaires / statistics & numerical data*