Aim: Description of the first documented case of imported hepatitis E, associated with geno- type 4 of HEV and introduced from southern France.
Materials and methods: Clinical, epidemio- logic and laboratory analysis of the imported case of disease of hepatitis E was carried out. Phylogenetic analysis of nucleotide sequences of HEV isolate, taken from the patient, was carried out.
Results: Epidemiologic analysis allowed to assume imported character of the detected case of HEV-infection. Comparative analysis ofnucleotide sequences of regions ofthe open reading frame 2 (300 nt) and open reading frame 1 (721 nt) of HEV genome, isolated from the patient, showed identity of this isolate with variants of genotype 4 HEV, isolated in France in 2009 - 2011 from patients with autochthonous hepatitis E.
Conclusion: The results obtained confirm the case of import into Russia of genotype 4 HEV from south-eastern France (Corsica), where spread of this virus genotype is observed in recent years.