Diffusion-weighted magnetic resonance imaging is useful for assessing inflammatory myopathies

Muscle Nerve. 2019 May;59(5):555-560. doi: 10.1002/mus.26438. Epub 2019 Feb 14.

Abstract

Introduction: Short tau inversion recovery (STIR) sequences in whole-body MRI are usually used for detecting muscle edema (ME) in inflammatory myopathies. We evaluated b-value 800 diffusion-weighted imaging (b800 DWI).

Methods: Two radiologists independently and a consensus reader retrospectively reexamined 60 patients with inflammatory myopathies and 15 controls. For each participant, 78 muscles were analyzed with 3 sets of imaging acquisitions: T1-weighted (T1) turbo spin echo and STIR; T1 and DWI; and T1, STIR and DWI. Mean edema per patient was compared between sequences. Agreement was evaluated.

Results: Diffusion-weighted imaging detected more ME compared with STIR (P < 0.001). Agreement between readers was better with both sequences (k = 0.94) than with b800 DWI (k = 0.89) or STIR (k = 0.84) alone.

Discussion: Diffusion-weighted imaging is a valuable add-on for the study of inflammatory myopathies. Muscle Nerve 59:555-555, 2019.

Keywords: diffusion magnetic resonance imaging; edema; inflammatory myopathy; muscular disease; whole body imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Creatine Kinase / blood
  • Dermatomyositis / blood
  • Dermatomyositis / diagnostic imaging
  • Dermatomyositis / pathology
  • Diffusion Magnetic Resonance Imaging
  • Edema / diagnostic imaging*
  • Female
  • Fructose-Bisphosphate Aldolase / blood
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal / diagnostic imaging*
  • Muscle, Skeletal / pathology
  • Myositis / blood
  • Myositis / diagnostic imaging*
  • Myositis / pathology
  • Myositis, Inclusion Body / blood
  • Myositis, Inclusion Body / diagnostic imaging
  • Myositis, Inclusion Body / pathology
  • Polymyositis / blood
  • Polymyositis / diagnostic imaging
  • Polymyositis / pathology
  • Retrospective Studies
  • Whole Body Imaging
  • Young Adult

Substances

  • Creatine Kinase
  • Fructose-Bisphosphate Aldolase