Fibroblasts: Dangerous travel companions

J Exp Med. 2019 Mar 4;216(3):479-481. doi: 10.1084/jem.20181850. Epub 2019 Feb 1.

Abstract

In this issue of JEM, Gao et al. (https://doi.org/10.1084/jem.20180765) demystify the exceptional metastatic success of ovarian cancer, the most lethal female malignancy: fibroblasts form heterotypic aggregates with disseminating cancer cells, thereby providing them with reciprocal signaling and matrix for adherence.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Female
  • Fibroblasts
  • Friends*
  • Humans
  • Ovarian Neoplasms*
  • Signal Transduction