Relevance of radium-223 in hospital clinical practice from a medical oncologist point of view

Rev Esp Med Nucl Imagen Mol (Engl Ed). 2019 Mar-Apr;38(2):106-111. doi: 10.1016/j.remn.2018.11.002. Epub 2019 Jan 30.
[Article in English, Spanish]

Abstract

Currently, there are several options available for the treatment of metastatic castration resistant prostate cancer (mCRPC), however evidence on the optimal treatment sequence is lacking. 223Ra is the first targeted alpha therapy that has shown an improvement in overall survival in mCRPC patients. This drug specifically targets bone lesions, so there is a window of opportunity for the administration of 223Ra previous to the development of visceral metastases. This should be taken into account to design the therapeutic strategy for mCRPC patients. It is necessary, therefore, to review the different approaches in routine clinical practice, to define best practices for patient selection and on-treatment monitoring.

Keywords: (223)Ra; Bone metastases; Castration-resistant prostate cancer; Cáncer de próstata resistente a la castración; Metástasis óseas; Overall survival; Supervivencia global.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Attitude of Health Personnel
  • Humans
  • Male
  • Medical Oncology
  • Prostatic Neoplasms / radiotherapy*
  • Radioisotopes / therapeutic use
  • Radium / therapeutic use*

Substances

  • Antineoplastic Agents
  • Radioisotopes
  • radium Ra 223 dichloride
  • Radium