Failure of syndromic management due to drug-resistant Mycoplasma genitalium infection in South Africa: a case report

Int J STD AIDS. 2019 Apr;30(5):519-521. doi: 10.1177/0956462418820745. Epub 2019 Feb 4.

Abstract

We report a case of management failure of male urethritis syndrome due to macrolide-resistant Mycoplasma genitalium in South Africa. We detected mutations in 23S rRNA and one of the quinolone resistance-determining regions. This report confirms that drug-resistant M. genitalium infection can undermine the effectiveness of syndromic management in Africa.

Keywords: Africa; Non-gonococcal urethritis; bacterial disease; location; men; other; treatment; urethritis (bacterial).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • DNA, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Dysuria / etiology
  • HIV Seronegativity
  • Humans
  • Lost to Follow-Up
  • Macrolides / pharmacology*
  • Male
  • Mycoplasma Infections / diagnosis
  • Mycoplasma Infections / drug therapy*
  • Mycoplasma Infections / microbiology
  • Mycoplasma genitalium / drug effects*
  • Mycoplasma genitalium / genetics*
  • Mycoplasma genitalium / isolation & purification
  • Quinolones / pharmacology*
  • RNA, Ribosomal, 23S / drug effects
  • RNA, Ribosomal, 23S / genetics*
  • Real-Time Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Urethritis / etiology

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Macrolides
  • Quinolones
  • RNA, Ribosomal, 23S