Gender-Based Differences in Cardiac Resynchronization Therapy Response

Marin Nishimura; Ulrika Birgersdotter-Green

doi:10.1016/j.ccep.2018.11.015

Gender-Based Differences in Cardiac Resynchronization Therapy Response

Card Electrophysiol Clin. 2019 Mar;11(1):115-122. doi: 10.1016/j.ccep.2018.11.015.

Authors

Marin Nishimura¹, Ulrika Birgersdotter-Green²

Affiliations

¹ Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, Mail Code 7411, La Jolla, CA 92037-7411, USA.
² Pacemaker and ICD Services, Cardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Diego, 9444 Medical Center Drive, MC 7411, La Jolla, CA 92037, USA. Electronic address: [email protected].

PMID: 30717843
DOI: 10.1016/j.ccep.2018.11.015

Abstract

Cardiac resynchronization therapy (CRT) has been shown to have a multitude of beneficial effects in select patients with systolic heart failure, by enhancing reverse remodeling, improving quality of life and functional status, reducing risk of heart failure admission, and most importantly, improving survival. Although women were underrepresented in the clinical trials, they were demonstrated to derive greater therapeutic benefit from CRT compared with men. Importantly, women were noted to derive benefit at a lesser degree of QRS prolongation than men, well below the now generally accepted cutoff of QRS ≥150 milliseconds.

Keywords: Cardiac resynchronization therapy; Gender; LBBB; QRS.

Publication types

Review

MeSH terms

Bundle-Branch Block
Cardiac Resynchronization Therapy*
Female
Humans
Male
Sex Factors
Treatment Outcome