Dual stimuli-responsive bispillar[5]arene-based nanoparticles for precisely selective drug delivery in cancer cells

Qian Cheng; Kun-Xu Teng; Yuan-Fu Ding; Ludan Yue; Qing-Zheng Yang; Ruibing Wang

doi:10.1039/c8cc09432b

Dual stimuli-responsive bispillar[5]arene-based nanoparticles for precisely selective drug delivery in cancer cells

Chem Commun (Camb). 2019 Feb 19;55(16):2340-2343. doi: 10.1039/c8cc09432b.

Authors

Qian Cheng¹, Kun-Xu Teng, Yuan-Fu Ding, Ludan Yue, Qing-Zheng Yang, Ruibing Wang

Affiliation

¹ State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China. [email protected].

PMID: 30724297
DOI: 10.1039/c8cc09432b

Abstract

Paclitaxel-loaded nanoparticles based on a bispillar[5]arene compound were successfully developed using a microemulsion method for the first time. The nanoparticles exhibited dual stimuli-responsiveness towards both spermine and glutathione, allowing precisely selective drug release in lung cancer cells that overexpress both stimuli.

MeSH terms

Biological Transport
Cell Line, Tumor
Drug Carriers / chemistry*
Drug Liberation
Glutathione / metabolism
Humans
Hydrocarbons, Aromatic / chemistry*
Hydrogen-Ion Concentration
Nanoparticles / chemistry*
Paclitaxel / chemistry
Paclitaxel / metabolism
Particle Size
Spermine / metabolism

Substances

Drug Carriers
Hydrocarbons, Aromatic
Spermine
Glutathione
Paclitaxel