Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay

Fujio Shiraishi; Ryo Kamata; Masanori Terasaki; Hidetaka Takigami; Yoshitaka Imaizumi; Mayuko Yagishita; Daisuke Nakajima

doi:10.1016/j.dib.2018.11.071

Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay

Data Brief. 2018 Nov 23:21:2543-2546. doi: 10.1016/j.dib.2018.11.071. eCollection 2018 Dec.

Authors

Fujio Shiraishi¹, Ryo Kamata², Masanori Terasaki³, Hidetaka Takigami¹, Yoshitaka Imaizumi¹, Mayuko Yagishita¹, Daisuke Nakajima¹

Affiliations

¹ National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
² Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan.
³ Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan.

Abstract

We screened 583 chemicals for receptor binding activity to the human estrogen receptor (hER), the Japanese medaka estrogen receptor (medER), and the aryl hydrocarbon receptor (AhR) using the yeast two-hybrid assay. The substances tested included substances that could potentially be produced unintentionally by industrial processes, such as halogenated steroids and phenols. Antagonistic effects on hER and the androgen receptor were also screened. The test chemicals were selected for screening on the basis of chemical structure associated with possible estrogen receptor binding activity. The current study presents the report on the screening of 583 chemicals for different kinds of endocrine disrupting activity.