SDF1α-induced chemotaxis of JAK2-V617F-positive cells is dependent on Bruton tyrosine kinase and its downstream targets PI3K/AKT, PLCγ1 and RhoA

Haematologica. 2019 Jul;104(7):e288-e292. doi: 10.3324/haematol.2018.201921. Epub 2019 Feb 14.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase / genetics
  • Agammaglobulinaemia Tyrosine Kinase / metabolism*
  • Cell Movement
  • Cells, Cultured
  • Chemokine CXCL12 / genetics
  • Chemokine CXCL12 / metabolism*
  • Chemotaxis*
  • Gene Expression Regulation*
  • Humans
  • Janus Kinase 2 / genetics
  • Janus Kinase 2 / metabolism*
  • Mutation*
  • Myeloid Progenitor Cells / cytology
  • Myeloid Progenitor Cells / physiology*
  • Phosphatidylinositol 3-Kinases / genetics
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phospholipase C gamma / genetics
  • Phospholipase C gamma / metabolism
  • Proto-Oncogene Proteins c-akt / genetics
  • Proto-Oncogene Proteins c-akt / metabolism
  • rhoA GTP-Binding Protein / genetics
  • rhoA GTP-Binding Protein / metabolism

Substances

  • CXCL12 protein, human
  • Chemokine CXCL12
  • RHOA protein, human
  • Agammaglobulinaemia Tyrosine Kinase
  • BTK protein, human
  • JAK2 protein, human
  • Janus Kinase 2
  • Proto-Oncogene Proteins c-akt
  • Phospholipase C gamma
  • rhoA GTP-Binding Protein