Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE)

J Rheumatol. 2019 Sep;46(9):1215-1221. doi: 10.3899/jrheum.181084. Epub 2019 Feb 15.

Abstract

Objective: To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis.

Methods: After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, and 33 entheses 0-3 separately for soft tissue inflammation and osteitis.

Results: In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κ ranged 0.35-0.77.

Conclusion: Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.

Keywords: ARTHRITIS; MAGNETIC RESONANCE IMAGING; OMERACT; OUTCOME ASSESSMENT.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Arthritis, Rheumatoid / diagnostic imaging*
  • Enthesopathy / diagnostic imaging*
  • Humans
  • Inflammation / diagnostic imaging
  • Magnetic Resonance Imaging / methods*
  • Reproducibility of Results
  • Whole Body Imaging / methods*