The role of R-loops in transcription-associated DNA double-strand break repair

Reona Kato; Kiyoshi Miyagawa; Takaaki Yasuhara

doi:10.1080/23723556.2018.1542244

The role of R-loops in transcription-associated DNA double-strand break repair

Mol Cell Oncol. 2019 Jan 22;6(1):1542244. doi: 10.1080/23723556.2018.1542244. eCollection 2019.

Authors

Reona Kato¹, Kiyoshi Miyagawa¹, Takaaki Yasuhara¹

Affiliation

¹ Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Abstract

The roles of RNA in the DNA damage response are emerging. We highlight findings from our recent study demonstrating the mechanism for transcription-associated homologous recombination repair (TA-HRR) of DNA double-strand breaks and the critical role of R-loops in TA-HRR.

Keywords: DNA double-strand break; DNA-RNA hybrid; R-loop; RAD52; XPG; transcription-associated homologous recombination repair.

Grants and funding

This work was supported by JSPS KAKENHI Grant Number JP15H06146 and JP18K18191 to T.Y., JP15H04902 and JP15K14376 to K.M.