LncRNAs join hands together to regulate neuroblastoma progression

Tanmoy Mondal; Chandrasekhar Kanduri

doi:10.1080/23723556.2018.1553697

LncRNAs join hands together to regulate neuroblastoma progression

Mol Cell Oncol. 2018 Dec 17;6(1):1553697. doi: 10.1080/23723556.2018.1553697. eCollection 2019.

Authors

Tanmoy Mondal¹, Chandrasekhar Kanduri¹

Affiliation

¹ Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Abstract

Trait associated single nucleotide polymorphisms often overlap with noncoding transcripts but their contribution to disease phenotype is poorly investigated. Our study on neuroblastoma risk associated 6p22.3 locus derived long noncoding RNAs (lncRNAs) demonstrates that functional co-operation between sense-antisense CASC15 and NBAT1 lncRNAs control neuroblastoma progression via regulating SOX9-CHD7-USP36 regulatory axis.

Keywords: GWAS SNPs; SOX9; USP36; lncRNA; neuroblastoma.

Grants and funding

Knut and AliceWallenberg Foundation [KAW2014.0057]; Swedish Foundation for Strategic Research [RB13 0204]; Swedish Cancer Research foundation [Cancerfonden: Kontrakt no. 150796]; Swedish Research Council [2017-02834]; Barncancerfonden [PR2016-0057]; and LUA/ ALF (to C.K.).