During June 2017-April 2018, active tuberculosis with Beijing SIT1 isolates was diagnosed in 14 persons living in 4 distant cities in France. Whole-genome sequencing indicated that these patients belonged to a single transmission chain. Whole-genome sequencing-based laboratory investigations enabled prompt tracing of linked cases to improve tuberculosis control.
Keywords: France; Mycobacterium tuberculosis; TB; Tuberculosis; bacteria; disease outbreaks; drug susceptibility; epidemiologic monitoring; tuberculosis and other mycobacteria; whole-genome sequencing.