Abstract
2'-Fucosyllactose (2'-FL) is a ubiquitous oligosaccharide in human milk. Importantly, this carbohydrate promotes the growth of several strains of Bifidobacteria, a class of beneficial gut commensal, and inhibits epithelial binding of pathogens. In light of these protective effects, we elected to evaluate the potential of 2'-FL to serve as an antibacterial agent against Group B Streptococcus (GBS). While 2'-FL was devoid of any substantial antimicrobial or antibiofilm activity, conversion of 2'-FL to its reducing end β-amine provided a novel antibiofilm compound.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Biofilms / drug effects*
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Biofilms / growth & development
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Carbohydrate Conformation
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Oligosaccharides / chemical synthesis*
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Oligosaccharides / chemistry
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Oligosaccharides / pharmacology*
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Streptococcus agalactiae / drug effects*
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Streptococcus agalactiae / physiology
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Oligosaccharides