Synaptic vesicle protein 2A as a potential biomarker in synaptopathies

Mol Cell Neurosci. 2019 Jun:97:34-42. doi: 10.1016/j.mcn.2019.02.001. Epub 2019 Feb 20.

Abstract

Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.

Keywords: Biomarkers; Position emission tomography; SV2A; Synaptopathies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Brain / diagnostic imaging*
  • Brain / metabolism*
  • Humans
  • Membrane Glycoproteins / metabolism*
  • Mental Disorders / diagnostic imaging
  • Mental Disorders / metabolism
  • Nerve Tissue Proteins / metabolism*
  • Neurodegenerative Diseases / diagnostic imaging*
  • Neurodegenerative Diseases / metabolism*
  • Positron-Emission Tomography / methods*
  • Synapses / metabolism

Substances

  • Biomarkers
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • SV2A protein, human