Electroconductive materials as biomimetic platforms for tissue regeneration

Katsuhiro Hosoyama; Manuel Ahumada; Keshav Goel; Marc Ruel; Erik J Suuronen; Emilio I Alarcon

doi:10.1016/j.biotechadv.2019.02.011

Electroconductive materials as biomimetic platforms for tissue regeneration

Biotechnol Adv. 2019 May-Jun;37(3):444-458. doi: 10.1016/j.biotechadv.2019.02.011. Epub 2019 Feb 20.

Authors

Katsuhiro Hosoyama¹, Manuel Ahumada², Keshav Goel¹, Marc Ruel¹, Erik J Suuronen³, Emilio I Alarcon⁴

Affiliations

¹ Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
² Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, United States; Department of Dermatology, Harvard Medical School, Boston, MA, United States.
³ Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address: [email protected].
⁴ Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.. Electronic address: [email protected].

PMID: 30797094
DOI: 10.1016/j.biotechadv.2019.02.011

Abstract

In many diseases, tissue regeneration is compromised and/or insufficient to restore tissue/organ function. Therefore, novel regenerative therapies are being developed to enhance resident and transplanted cell proliferation and functional differentiation. Numerous biomaterials engineered to include nanocomponents have emerged as promising candidates to fulfil the need of mimicking the properties of the healthy extracellular matrix. This is particularly important for tissues that require electroconductive support to achieve optimal cellular function, such as muscles and neurons. In this review, we summarize and discuss the current state-of-the-art for electroconductive materials in tissue regeneration, with particular emphasis on materials containing nanocomponents.

Keywords: Biomimetic templates; Electroconductive material; Nanomaterials; Stem cell; Tissue engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomimetic Materials / chemistry*
Biomimetic Materials / therapeutic use
Extracellular Matrix / drug effects
Humans
Regeneration / drug effects*
Regenerative Medicine / trends
Tissue Engineering / trends*
Wound Healing / drug effects*

Grants and funding

CIHR/Canada