Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

Claudio Babiloni; Claudio Del Percio; Maria Teresa Pascarelli; Roberta Lizio; Giuseppe Noce; Susanna Lopez; Marco Rizzo; Raffaele Ferri; Andrea Soricelli; Flavio Nobili; Dario Arnaldi; Francesco Famà; Francesco Orzi; Carla Buttinelli; Franco Giubilei; Marco Salvetti; Virginia Cipollini; Raffaella Franciotti; Marco Onofrj; Paola Stirpe; Peter Fuhr; Ute Gschwandtner; Gerhard Ransmayr; Dag Aarsland; Lucilla Parnetti; Lucia Farotti; Moira Marizzoni; Fabrizia D'Antonio; Carlo De Lena; Bahar Güntekin; Lutfu Hanoğlu; Görsev Yener; Derya Durusu Emek-Savaş; Antonio Ivano Triggiani; John Paul Taylor; Ian McKeith; Fabrizio Stocchi; Laura Vacca; Harald Hampel; Giovanni B Frisoni; Maria Francesca De Pandis; Laura Bonanni

doi:10.1016/j.neurobiolaging.2019.01.013

Abnormalities of functional cortical source connectivity of resting-state electroencephalographic alpha rhythms are similar in patients with mild cognitive impairment due to Alzheimer's and Lewy body diseases

Neurobiol Aging. 2019 May:77:112-127. doi: 10.1016/j.neurobiolaging.2019.01.013. Epub 2019 Jan 24.

Authors

Claudio Babiloni¹, Claudio Del Percio², Maria Teresa Pascarelli³, Roberta Lizio⁴, Giuseppe Noce⁴, Susanna Lopez², Marco Rizzo⁵, Raffaele Ferri⁵, Andrea Soricelli⁶, Flavio Nobili⁷, Dario Arnaldi⁷, Francesco Famà⁸, Francesco Orzi⁹, Carla Buttinelli⁹, Franco Giubilei⁹, Marco Salvetti¹⁰, Virginia Cipollini⁹, Raffaella Franciotti¹¹, Marco Onofrj¹¹, Paola Stirpe¹², Peter Fuhr¹³, Ute Gschwandtner¹³, Gerhard Ransmayr¹⁴, Dag Aarsland¹⁵, Lucilla Parnetti¹⁶, Lucia Farotti¹⁶, Moira Marizzoni¹⁷, Fabrizia D'Antonio¹⁸, Carlo De Lena¹⁸, Bahar Güntekin¹⁹, Lutfu Hanoğlu²⁰, Görsev Yener²¹, Derya Durusu Emek-Savaş²², Antonio Ivano Triggiani²³, John Paul Taylor²⁴, Ian McKeith²⁴, Fabrizio Stocchi¹², Laura Vacca¹², Harald Hampel²⁵, Giovanni B Frisoni²⁶, Maria Francesca De Pandis²⁷, Laura Bonanni¹¹

Affiliations

¹ Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy; Hospital San Raffaele Cassino, Cassino (FR), Italy. Electronic address: [email protected].
² Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy.
³ Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy; Oasi Research Institute - IRCCS, Troina, Italy.
⁴ IRCCS SDN, Napoli, Italy.
⁵ Oasi Research Institute - IRCCS, Troina, Italy.
⁶ IRCCS SDN, Napoli, Italy; Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy.
⁷ Clinica Neurologica, IRCCS Ospedale Policlinico San Martino, Genova, Italy; Dipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-infantili (DiNOGMI), Università di Genova, Genova, Italy.
⁸ Dipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-infantili (DiNOGMI), Università di Genova, Genova, Italy.
⁹ Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy.
¹⁰ Department of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy; Neuromed: IRCCS Istituto Neurologico Mediterraneo (INM) Neuromed Pozzilli, Isernia, Italy.
¹¹ Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy.
¹² IRCCS San Raffaele Pisana, Rome, Italy.
¹³ Universitätsspital Basel, Abteilung Neurophysiologie, Basel, Switzerland.
¹⁴ Department of Neurology 2, Med Campus III, Faculty of Medicine, Johannes Kepler University, Kepler University Hospital, Linz, Austria.
¹⁵ Department of Old Age Psychiatry, King's College University, London, UK.
¹⁶ Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
¹⁷ Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
¹⁸ Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
¹⁹ Department of Biophysics, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
²⁰ Department of Neurology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
²¹ Department of Neurosciences and Department of Neurology, Dokuz Eylül University Medical School, Izmir, Turkey.
²² Department of Psychology and Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey.
²³ Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
²⁴ Institute of Neuroscience, Newcastle University, Newcastle, UK.
²⁵ Department of Neurology, Institute of Memory and Alzheimer's Disease (IM2A), Brain and Spine Institute (ICM), Paris, France.
²⁶ Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
²⁷ Hospital San Raffaele Cassino, Cassino (FR), Italy.

PMID: 30797169
DOI: 10.1016/j.neurobiolaging.2019.01.013

Abstract

Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Here, clinical and resting-state eyes-closed electroencephalographic data in age-, gender-, and education-matched 30 ADMCI, 23 DLBMCI, and 30 healthy elderly (Nold) subjects were available in our international archive. Mini-Mental State Evaluation (MMSE) score was matched in the ADMCI and DLBMCI groups. The eLORETA freeware estimated delta and alpha source connectivity by the tool called lagged linear connectivity (LLC). Area under receiver operating characteristic curve (AUROCC) indexed the classification accuracy among individuals. Results showed that widespread interhemispheric and intrahemispheric LLC solutions in alpha sources were abnormally lower in both MCI groups compared with the Nold group, but with no differences were found between the 2 MCI groups. AUROCCs of LLC solutions in alpha sources exhibited significant accuracies (0.72-0.75) in the discrimination of Nold versus ADMCI-DLBMCI individuals, but not between the 2 MCI groups. These findings disclose similar abnormalities in ADMCI and DLBMCI patients as revealed by alpha source connectivity. It can be speculated that source connectivity mostly reflects common cholinergic impairment in prodromal state of both AD and DLB, before a substantial dopaminergic derangement in the dementia stage of DLB.

Keywords: Functional brain connectivity; Mild cognitive impairment due to Alzheimer's disease (ADMCI); Mild cognitive impairment due to dementia with Lewy body (DLBMCI); Resting state EEG rhythms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alpha Rhythm*
Alzheimer Disease / complications*
Cerebral Cortex / physiopathology*
Cognitive Dysfunction / etiology*
Cognitive Dysfunction / physiopathology*
Female
Humans
Lewy Body Disease / complications*
Male
Rest / physiology*