Design of ruthenium-albumin hydrogel for cancer therapeutics and luminescent imaging

Zhiquan Zhao; Rentao Hu; Hongdong Shi; Yi Wang; Liangnian Ji; Pingyu Zhang; Qianling Zhang

doi:10.1016/j.jinorgbio.2019.02.002

Design of ruthenium-albumin hydrogel for cancer therapeutics and luminescent imaging

J Inorg Biochem. 2019 May:194:19-25. doi: 10.1016/j.jinorgbio.2019.02.002. Epub 2019 Feb 10.

Authors

Zhiquan Zhao¹, Rentao Hu¹, Hongdong Shi¹, Yi Wang¹, Liangnian Ji², Pingyu Zhang³, Qianling Zhang⁴

Affiliations

¹ Department of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, PR China.
² Department of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China.
³ Department of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, PR China. Electronic address: [email protected].
⁴ Department of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, PR China. Electronic address: [email protected].

PMID: 30798078
DOI: 10.1016/j.jinorgbio.2019.02.002

Abstract

Improving cell uptake of metal compounds has became an important goal in the field of metal-based anticancer agents. This may combat platinum resistance and side effects seen commonly in current anticancer chemotherapy regimes. Here, we explore a novel degradable ruthenium-albumin hydrogel, which shows strong luminescence for cell imaging and high selectivity for cancer cells versus non-cancer cells. This is an early indication of the possibility of reducing unwanted side effects of metals by using bovine serum albumin hydrogel as a delivery strategy. This work provides a strong basis for development of a new class of metal-based cancer therapeutic agents.

Keywords: Albumin; Hydrogel; Imaging; Ruthenium; Therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Antineoplastic Agents / toxicity
Cattle
Cell Line, Tumor
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Coordination Complexes / toxicity
Endopeptidase K / chemistry
Humans
Hydrogels / chemical synthesis
Hydrogels / chemistry*
Hydrogels / toxicity
Luminescent Agents / chemical synthesis
Luminescent Agents / chemistry*
Luminescent Agents / toxicity
Lysosomes / metabolism
Microscopy, Confocal
Mitochondria / metabolism
Proteolysis
Ruthenium / chemistry*
Serum Albumin, Bovine / chemistry*
Serum Albumin, Bovine / toxicity

Substances

Antineoplastic Agents
Coordination Complexes
Hydrogels
Luminescent Agents
Serum Albumin, Bovine
Ruthenium
Endopeptidase K