Abstract
Natural killer (NK) cell have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / biosynthesis
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Antibodies, Monoclonal / physiology
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Antigens, Differentiation, T-Lymphocyte
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Antigens, Surface / analysis
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Antigens, Surface / immunology*
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Binding, Competitive
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Cell Line
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Cytotoxicity, Immunologic*
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Humans
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Hybridomas / metabolism
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Killer Cells, Natural / classification
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Killer Cells, Natural / immunology*
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Lymphocyte Activation
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Lymphocyte Function-Associated Antigen-1
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Mice
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Mice, Inbred BALB C
Substances
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Antibodies, Monoclonal
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Antigens, Differentiation, T-Lymphocyte
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Antigens, Surface
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Lymphocyte Function-Associated Antigen-1