A B-cell receptor-related gene signature predicts response to ibrutinib treatment in mantle cell lymphoma cell lines

Haematologica. 2019 Sep;104(9):e410-e414. doi: 10.3324/haematol.2018.212811. Epub 2019 Feb 28.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / analogs & derivatives
  • Agammaglobulinaemia Tyrosine Kinase / genetics
  • Antineoplastic Agents / pharmacology
  • Biomarkers, Tumor / genetics
  • CD79 Antigens / genetics
  • Cell Line, Tumor
  • Class I Phosphatidylinositol 3-Kinases / genetics
  • Gene Expression Profiling*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Immunotherapy
  • Leukocytes, Mononuclear / cytology
  • Lymphoma, Mantle-Cell / drug therapy
  • Lymphoma, Mantle-Cell / genetics*
  • Neoplasm Recurrence, Local
  • Piperidines
  • Prognosis
  • Progression-Free Survival
  • Proto-Oncogene Proteins c-akt / genetics
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Pyrazoles / pharmacology*
  • Pyrimidines / pharmacology*
  • Randomized Controlled Trials as Topic
  • Receptors, Antigen, B-Cell / genetics*
  • Recurrence
  • Stem Cell Transplantation
  • Syk Kinase / genetics
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • BCL2 protein, human
  • Biomarkers, Tumor
  • CD79 Antigens
  • CD79B protein, human
  • Piperidines
  • Proto-Oncogene Proteins c-bcl-2
  • Pyrazoles
  • Pyrimidines
  • Receptors, Antigen, B-Cell
  • ibrutinib
  • Class I Phosphatidylinositol 3-Kinases
  • PIK3CD protein, human
  • Agammaglobulinaemia Tyrosine Kinase
  • BTK protein, human
  • SYK protein, human
  • Syk Kinase
  • AKT3 protein, human
  • Proto-Oncogene Proteins c-akt
  • Adenine