FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics

J Antibiot (Tokyo). 1986 Feb;39(2):198-204. doi: 10.7164/antibiotics.39.198.

Abstract

A PAF antagonist, designated as FR-900452, was isolated from fermentation products of Streptomyces phaeofaciens and the molecular formula was determined as C22H25N3O3S. The compound inhibited PAF-induced rabbit platelet aggregation with an IC50 of 3.7 X 10(-7)M, but was much less active against collagen-, arachidonic acid- or ADP-induced aggregation (IC50; 6.4 X 10(-5), greater than 10(-4) or greater than 10(-4)M, respectively).

MeSH terms

  • Adenosine Diphosphate / pharmacology
  • Animals
  • Arachidonic Acid
  • Arachidonic Acids / pharmacology
  • Chemical Phenomena
  • Chemistry
  • Collagen / pharmacology
  • Fermentation*
  • Indoles*
  • Piperazines*
  • Platelet Activating Factor* / antagonists & inhibitors*
  • Platelet Activating Factor* / isolation & purification
  • Platelet Activating Factor* / pharmacology
  • Platelet Aggregation / drug effects
  • Rabbits
  • Streptomyces / classification
  • Streptomyces / metabolism*

Substances

  • Arachidonic Acids
  • Indoles
  • Piperazines
  • Platelet Activating Factor
  • FR 900452
  • Arachidonic Acid
  • Adenosine Diphosphate
  • Collagen