POSS-based supramolecular amphiphilic zwitterionic complexes for drug delivery

Biomater Sci. 2019 Apr 23;7(5):1984-1994. doi: 10.1039/c9bm00125e.

Abstract

Zwitterionic complexes in aqueous solutions have been extensively explored as the most promising candidate in drug delivery systems for targeted cancer chemotherapy. A POSS-based supramolecular AD-POSS-(sulfobetaine)7/CD-PLLA zwitterionic complex has been fabricated via a combination of efficient click chemistry and host-guest interaction. The well-defined POSS-based zwitterionic polymer could self-assemble into spherical nanoparticles that encapsulated a model cancer drug (DOX) and exhibited drug release in a controlled manner in a faintly acidic environment. On account of the hydrophilic block with cationic and anionic groups in the microscopic range that can form a hydration layer via electrostatic interactions, these drug-loaded nanoparticles exhibited excellent stability in a tumor intracellular microenvironment or under other pH conditions as revealed by dynamic light scattering (DLS) and zeta potential measurements. In vitro experiments demonstrated that these POSS-based nanoparticles had high resistance to non-specific protein absorption and low cytotoxicity against normal cells. Moreover, these DOX-loaded aggregates could be accumulated and effectively internalized by HeLa and MCF-7 tumor cells, exhibiting effective cellular proliferation inhibition via the release of anticancer agents. Therefore, these POSS-based supramolecular amphiphilic zwitterionic complexes, relying on the simple supramolecular interaction and efficient click reaction, could further emerge as a potential universal anticancer drug nanocarrier system for multifunctional cancer chemotherapy.

MeSH terms

  • 3T3 Cells
  • Absorption, Physicochemical
  • Animals
  • Biological Transport
  • Cattle
  • Cell Proliferation / drug effects
  • Doxorubicin / chemistry
  • Drug Carriers / chemistry*
  • Drug Carriers / metabolism
  • Drug Carriers / toxicity
  • Drug Liberation
  • Humans
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions*
  • MCF-7 Cells
  • Materials Testing
  • Mice
  • Nanoparticles / chemistry
  • Organosilicon Compounds / chemistry*
  • Organosilicon Compounds / metabolism
  • Organosilicon Compounds / toxicity
  • Polyesters / chemistry
  • Serum Albumin, Bovine / chemistry

Substances

  • Drug Carriers
  • Organosilicon Compounds
  • Polyesters
  • polyhedraloligosilsesquioxane
  • Serum Albumin, Bovine
  • poly(lactide)
  • Doxorubicin