Validation of a point-of-care rapid diagnostic test for hepatitis C for use in resource-limited settings

Int Health. 2019 Jul 1;11(4):314-315. doi: 10.1093/inthealth/ihy101.

Abstract

Background: Treatment of HCV with direct-acting antivirals has enabled the discussion of HCV eradication worldwide. Envisioning this aim requires implementation of mass screening in resource-limited areas, usually constrained by testing costs.

Methods: We validated a low-cost, rapid diagnosis test (RDT) for HCV in three different continents in 141 individuals.

Results: The HCV RDT showed 100% specificity and sensitivity across different samples regardless of genotype or viral load (in samples with such information, 90%).

Conclusions: The HCV test validated in this study can allow for HCV screening in areas of need when properly used.

Keywords: hepatitis C; rapid diagnostic test; resource-limited.

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Costs and Cost Analysis*
  • Diagnostic Tests, Routine* / economics
  • Health Resources*
  • Hepacivirus* / genetics
  • Hepacivirus* / growth & development
  • Hepatitis C / diagnosis*
  • Hepatitis C / economics
  • Hepatitis C / virology
  • Humans
  • Mass Screening / economics
  • Mass Screening / methods*
  • Point-of-Care Systems* / economics
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Viral Load