Abstract
Several new quinolone derivatives were investigated for their influence on human lymphocyte blastogenesis and gamma-interferon production following concanavalin A stimulation. All the antimicrobials induced inhibition of lymphocyte DNA synthesis. The gamma-interferon measurements showed that nalidixic acid and norfloxacin have a negative influence on lymphokine production and release.
MeSH terms
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Adult
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Anti-Infective Agents / pharmacology*
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DNA / biosynthesis
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Humans
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In Vitro Techniques
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Interferon-gamma / biosynthesis*
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Lymphocyte Activation / drug effects*
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Lymphocytes / drug effects
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Lymphocytes / metabolism
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Male
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Middle Aged
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Nalidixic Acid / pharmacology
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Norfloxacin / pharmacology
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Ofloxacin
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Oxazines / pharmacology
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Pipemidic Acid / pharmacology
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Piromidic Acid / pharmacology
Substances
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Anti-Infective Agents
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Oxazines
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Nalidixic Acid
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Piromidic Acid
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Interferon-gamma
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DNA
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Ofloxacin
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Pipemidic Acid
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Norfloxacin