Paget's Diseases: United by Epidermis and Epigenetics

J Invest Dermatol. 2019 Apr;139(4):753-754. doi: 10.1016/j.jid.2018.10.001.

Abstract

Almost 150 years have passed since Sir James Paget described the disease that bears his name, but the molecular etiology and cellular origins of Paget's disease remain poorly understood. Herein, Zhang et al. (2018) bring Paget's disease into the genomics era, providing evidence for an epidermal origin for Paget's disease, as well as a high incidence of mutations in genes encoding epigenetic regulators.

Publication types

  • Comment

MeSH terms

  • Chromatin Assembly and Disassembly
  • Epidermis
  • Epigenesis, Genetic
  • Exome Sequencing
  • Humans
  • Mutation
  • Paget Disease, Extramammary*