Characterization of mcr-5-Harboring Salmonella enterica subsp. enterica Serovar Typhimurium Isolates from Animal and Food Origin in Germany

Antimicrob Agents Chemother. 2019 May 24;63(6):e00063-19. doi: 10.1128/AAC.00063-19. Print 2019 Jun.

Abstract

We characterized eight mcr-5-positive Salmonella enterica subsp. enterica serovar Typhimurium sequence type 34 (ST34) isolates obtained from pigs and meat in Germany. Five plasmid types were identified harboring mcr-5 on Tn6452 or putative mobile insertion cassettes. The mobility of mcr-5 was confirmed by integration of Tn6452 into the bacterial chromosomes of two strains and the detection of conjugative mcr-5 plasmids. The association with mobile genetic elements might further enhance mcr-5 distribution.

Keywords: Salmonella; colistin resistance; mcr-5; plasmids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Colistin / pharmacology*
  • Drug Resistance, Bacterial
  • Ethanolaminephosphotransferase / genetics*
  • Germany
  • Humans
  • Meat / microbiology*
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Salmonella Infections / microbiology*
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / enzymology
  • Salmonella typhimurium / genetics*
  • Swine

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Ethanolaminephosphotransferase
  • Colistin