Substituent-Oriented Synthesis of Substituted Pyrazoles/Chromeno[3,2- c]pyrazoles via Sequential Reactions of Chromones/3-Chlorochromones and Tosylhydrazones

J Org Chem. 2019 May 3;84(9):5913-5921. doi: 10.1021/acs.joc.9b00282. Epub 2019 Apr 2.

Abstract

A facile and efficient synthetic strategy for the chemoselective synthesis of monocyclic/tricyclic-fused pyrazoles was developed, and it was oriented by different 3-position substituents (H or Cl) on the chromones. The reaction proceeded in a one-pot sequential way with a broad substrate scope and moderate to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't