RETRACTED: HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma

Haotian Wang; Rujiang Jia; Tiansuo Zhao; Xin Li; Mingxiao Lang; Chungen Lan; Hongwei Wang; Zengxun Li; Bodong Zhou; Liangliang Wu; Yan Sun; Xiuchao Wang; He Ren; Jihui Hao

doi:10.1016/j.canlet.2019.03.036

RETRACTED: HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma

Cancer Lett. 2019 Jul 1:453:10-20. doi: 10.1016/j.canlet.2019.03.036. Epub 2019 Mar 25.

Authors

Haotian Wang¹, Rujiang Jia¹, Tiansuo Zhao¹, Xin Li¹, Mingxiao Lang¹, Chungen Lan¹, Hongwei Wang¹, Zengxun Li¹, Bodong Zhou¹, Liangliang Wu¹, Yan Sun¹, Xiuchao Wang², He Ren³, Jihui Hao⁴

Affiliations

¹ Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Department of Pancreatic Cancer, Tianjin, China.
² Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Department of Pancreatic Cancer, Tianjin, China. Electronic address: [email protected].
³ Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Department of Pancreatic Cancer, Tianjin, China. Electronic address: [email protected].
⁴ Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Department of Pancreatic Cancer, Tianjin, China. Electronic address: [email protected].

PMID: 30922919
DOI: 10.1016/j.canlet.2019.03.036

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief and Authors. Following concerns raised in the public domain, the authors contacted the journal to request the retraction of the article. Sections of panels from various figures appear similar to each other, particularly panels from Figures 3G and 5B, 3G and 5F, 3F, S4D, S5D, S5C and S10C, as well as S10E.

Keywords: GM-CSF; HIF-1α; Pancreatic ductal adenocarcinoma; Tumor-nerve interactions.

Publication types

Research Support, Non-U.S. Gov't
Retracted Publication

MeSH terms

Adult
Aged
Animals
Carcinoma, Pancreatic Ductal / metabolism
Carcinoma, Pancreatic Ductal / pathology*
Cell Line, Tumor
Cell Movement / physiology
Female
Granulocyte-Macrophage Colony-Stimulating Factor / antagonists & inhibitors
Granulocyte-Macrophage Colony-Stimulating Factor / metabolism*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / antagonists & inhibitors
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
Male
Mice
Mice, Nude
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Pancreatic Neoplasms / metabolism
Pancreatic Neoplasms / pathology*
Peripheral Nerves / pathology
Schwann Cells / metabolism
Schwann Cells / pathology*
Up-Regulation

Substances

HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
Granulocyte-Macrophage Colony-Stimulating Factor