Abstract
A series of cyclic lipidated oligo-Arg cell penetrating peptides were synthesised with varied macrocycle size and lipid chain anchoring site. The study of their cellular uptake revealed different structural requirements to promote efficient glycosaminoglycan-dependent endocytosis and direct translocation.
MeSH terms
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Amino Acid Sequence
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Animals
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CHO Cells
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Cell-Penetrating Peptides / chemical synthesis
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Cell-Penetrating Peptides / chemistry*
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Cell-Penetrating Peptides / metabolism
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Cricetinae
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Cricetulus
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Cyclization
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Endocytosis
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Glycosaminoglycans / chemistry*
Substances
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Cell-Penetrating Peptides
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Glycosaminoglycans